Case contributed by Dr Maciej Debowski Show
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Citation, DOI & case dataCitation: Debowski, M. Prostate cancer staging groups - AJCC 8th edition (table). Case study, Radiopaedia.org. (accessed on 12 Oct 2022) https://doi.org/10.53347/rID-65284 DOI: https://doi.org/10.53347/rID-65284 Permalink: https://radiopaedia.org/cases/65284 rID: 65284 Revisions: 2 times by 2 users - see full revision history Published: 3rd Jan 2019 Systems: Urogenital, Oncology Sections: - Tags: - Institution: Royal Brisbane and Women's Hospital Inclusion in quiz mode: Included
From the case: Prostate cancer staging groups - AJCC 8th edition (table)
Prostate cancer stage groups are determined by TNM, pretreatment serum PSA and histologic grade 1. References1 article features images from this case
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Related Radiopaedia articlesPromoted articles (advertising)The American Joint Committee on Cancer (AJCC) tumor, node, metastasis classification system (TNM) staging manual has been updated and provides more specified stage grouping for prostate cancer (PCa). We aimed to validate the updated AJCC stage groups for PCa using a radical prostatectomy (RP) cohort. We analyzed
the data of 3032 patients previously treated with RP for localized PCa. We stratified patients into stage groups according to the 8th edition of the AJCC manual and compared biochemical recurrence (BCR)-free survival using Kaplan-Meier analyses. There were 217 patients in stage group I, 33 in IIA, 1101 in IIB, 535 in IIC, 129 in IIIA, 781 in IIIB, and 236 in IIIC. There were no significant differences in BCR-free survival between stage groups IIC and IIIA (P =
.875). Subsequently, the low–Gleason score (GS) IIIA subgroup (GS ≤ 3 + 4, P = .025) showed superior BCR-free survival than the IIC group, and the high-GS IIIA subgroups (GS ≥ 4 + 3, P = .004) showed a poorer BCR-free survival than the IIC group. Furthermore, there were no significant differences between groups I and IIA (P = 330) and between groups IIA and IIB (P = .942). Our new staging system provided a better ability
to discriminate the prognosis of each group. However, our study has several limitations, such as retrospective design, relatively short follow-up period, and need for further validation. The current AJCC prognostic groups show some contradictory results, particularly concerning prognosis of the IIC and IIIA groups. We suggest that GS be given more weight than serum prostate-specific antigen level in stage group stratification. To read this article in full you will need to make a payment Global cancer statistics, 2012. Annual report to the nation on the status of cancer, 1975-2012, featuring the increasing incidence of liver cancer. Gleason grade progression is uncommon.
High-risk prostate cancer in the United States, 1990-2007. World J Urol. 2008; 26: 211
Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer. J Clin Oncol. 2010; 28: 126
Updated clinical results of active surveillance of very-low-risk prostate cancer in Korean men: 8 years of follow-up. Investig Clin Urol. 2017; 58: 164
Beyond PSA: The next generation of prostate cancer biomarkers. Sci Transl Med. 2012; 4: 127rv3
Prognostic factors of prostate cancer mortality in a Finnish randomized screening trial. Int J Urol. 2018; 25: 270-276
Biomarkers in prostate cancer: what's new?. Curr Opin Oncol. 2014; 26: 259
Prostate cancer—major changes in the American Joint Committee on Cancer 8th edition cancer staging manual. CA Cancer J Clin. 2017; 67: 245
Assessment of the prognostic value of the 8th AJCC staging system for patients with clinically staged prostate cancer; a time to sub-classify stage IV?. PLoS One. 2017; 12: e0188450
Prostate. in: Amin M.B. Edge S.B. Greene F.L. AJCC Cancer Staging Manual. 8th ed. Springer, New York, NY2017: 715
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Evaluation of the major changes in 8th edition of the American Joint Committee on Cancer pathological staging for prostate cancer treated with prostatectomy. PLoS One. 2017; 12: e0187887
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Validation of American Joint Committee on Cancer 8th staging system among prostate cancer patients treated with radical prostatectomy. Ther Adv Urol. 2017; 10: 35
A contemporary prostate cancer grading system: a validated alternative to the Gleason score. Eur Urol. 2016; 69: 428
Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med. 2013; 368: 436
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The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system. Am J Surg Pathol. 2016; 40: 244Article InfoPublication HistoryPublished online: October 31, 2018 Accepted: October 24, 2018 Received in revised form: October 24, 2018 Received: July 14, 2018 IdentificationDOI: https://doi.org/10.1016/j.clgc.2018.10.015 Copyright© 2018 Elsevier Inc. All rights reserved. ScienceDirectAccess this article on ScienceDirectRelated ArticlesWhat is the AJCC 8th edition?A standardized and contemporary cancer staging system that facilitates accurate risk stratification is essential to guide patient treatment. The eighth edition of the AJCC staging system is currently the most widely accepted approach to melanoma staging and classification at initial diagnosis.
How do you cite the AJCC 8th edition?Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, et al. (Eds.). AJCC Cancer Staging Manual (8th edition). Springer International Publishing: American Joint Commission on Cancer; 2017 [cited 2016 Dec 28].
Is there an AJCC 9th edition?Currently, there are no plans to publish a traditional printed AJCC manual for Version 9.
What is the AJCC staging system?The AJCC Cancer Staging System describes the severity of an individual's cancer based on the magnitude of the original (primary) tumor as well as on the extent cancer has spread in the body. Understanding the stage of the cancer helps doctors to develop a prognosis and design a treatment plan for individual patients.
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