Your lymph nodes play a vital role in your body's ability to fight off infections. Common areas where you might notice swollen lymph nodes include your neck, under your chin, in your armpits and in your groin.
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Swollen lymph nodes
Swollen lymph nodes
One of the most common places to find swollen lymph nodes is in the neck. The inset shows three swollen lymph nodes below the lower jaw.
Swollen lymph nodes usually occur as a result of infection from bacteria or viruses. Rarely, swollen lymph nodes are caused by cancer.
Your lymph nodes, also called lymph glands, play a vital role in your body's ability to fight off infections. They function as filters, trapping viruses, bacteria and other causes of illnesses before they can infect other parts of your body. Common areas where you might notice swollen lymph nodes include your neck, under your chin, in your armpits and in your groin.
In some cases, the passage of time and warm compresses may be all you need to treat swollen lymph nodes. If an infection causes swollen lymph nodes, treatment depends on the cause.
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Symptoms
Your lymphatic system is a network of organs, vessels and lymph nodes situated throughout your body. Many lymph nodes are located in your head and neck region. Lymph nodes that frequently swell are in this area, as well as in your armpits and groin area.
Swollen lymph nodes are a sign that something is wrong somewhere in your body. When your lymph nodes first swell, you might notice:
- Tenderness and pain in the lymph nodes
- Swelling that may be the size of a pea or kidney bean, or even larger in the lymph nodes
Depending on the cause of your swollen lymph nodes, other signs and symptoms you might have include:
- Runny nose, sore throat, fever and other indications of an upper respiratory infection
- General swelling of lymph nodes throughout your body. When this occurs, it may indicate an infection, such as HIV or mononucleosis, or an immune system disorder, such as lupus or rheumatoid arthritis
- Hard, fixed, rapidly growing nodes, indicating a possible cancer or lymphoma
- Fever
- Night sweats
When to see a doctor
Some swollen lymph nodes return to normal when the underlying condition, such as a minor infection, gets better. See your doctor if you're concerned or if your swollen lymph nodes:
- Have appeared for no apparent reason
- Continue to enlarge or have been present for two to four weeks
- Feel hard or rubbery, or don't move when you push on them
- Are accompanied by persistent fever, night sweats or unexplained weight loss
Seek immediate medical care if you're having difficulty swallowing or breathing.
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There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Email ErrorEmail field is required ErrorInclude a valid email address To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Lymph nodes, sometimes referred to as lymph glands, are an important part of the immune system. Lymph nodes are clustered throughout the body and function as filters, removing foreign particles from fluids that run through the vessels of the lymphatic system. Within lymph nodes are white blood cells called lymphocytes that help neutralize foreign agents like bacteria. Swollen lymph nodes are a sign that the body is fighting infection, and they may be tender and painful. In some cases, swollen lymph nodes may be a sign of cancer. This article describes lymph node structure and function, and the types of lymph nodes found throughout the body. It lists some conditions that can affect them and offers information about when you should contact a healthcare provider about a swollen lymph node.From Mayo Clinic to your inbox
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Lymph Node Structure
Lymph nodes are small, bean-shaped organs that are part of the lymphatic system. The lymphatic system is a network of vessels and organs that isolate and neutralize foreign agents and particles that can do the body harm.
In addition to lymph nodes, lymphatic fluid, and lymphatic vessels, the system is comprised of the thymus gland, tonsils, spleen, and bone marrow.
Lymph nodes vary in size from a few millimeters to up to 2 centimeters in diameter. There are hundreds located throughout the body, but they are mainly clustered in certain parts of the body.
Lymph Node Function
Lymph nodes work to identify and filter out foreign agents that cause infections. To do this, lymph nodes contain two different types of white blood cells:
- B lymphocytes (B cells) that produce antibodies to help fight bacteria, viruses, fungi, and other infectious agents
- T lymphocytes (T cells) that launch the adaptive immune response (an immune response specific to an infectious agent)
When a foreign agent has been trapped and the immune defenses are activated, the body will respond with inflammation. This causes the lymph nodes to swell.
Swollen lymph nodes, referred to as lymphadenopathy, can often be felt and seen, but not always. Some may be painful; others are not.
Not every particle that is filtered by the lymph nodes can be neutralized. One example is cancer cells that are shed from a nearby tumor. Even though lymph nodes cannot kill the cancer cells, they may be able to isolate and contain them during the early stages of the disease.
When to See a Healthcare Provider
Lymph nodes may remain swollen for up to two weeks. If they don't get better or keep getting bigger, contact your healthcare provider.
Are Swollen Lymph Nodes a Sign of Cancer?
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Click Play to Learn More About Lymph Nodes
This video has been medically reviewed by Benjamin F. Asher, MD
Types and Locations
Lymph nodes are clustered throughout the body in key locations. These include the armpits, neck, groin, upper abdomen, and mediastinum (the area between the lungs that contains all the principal organs of the chest).
Swollen lymph nodes in the armpits, neck, and groin can often be felt. Those in the mediastinum and upper abdomen may only be revealed with imaging tests such as a computed tomography (CT) scan or ultrasound.
The types and locations of lymph nodes vary as follows:
Cervical Lymph Nodes
Cervical lymph nodes are those in the neck. They are further broken down by their location:
- Anterior cervical lymph nodes are those nearest the front of the neck. These typically swell when you have a cold or strep throat.
- Posterior cervical lymph nodes are located behind the band of muscles on the side of the neck. These often swell when you have infectious mononucleosis.
- Occipital lymph nodes are located at the back of the neck at the base of the skull. These often swell with infections like HIV.
Axillary Lymph Nodes
Axillary lymph nodes are the lymph nodes located in the armpit (axilla). There are usually between 10 and 40 lymph nodes in the axilla.
The axillary lymph nodes are important in the diagnosis of breast cancer. When cancer cells are shed from a breast tumor, they first travel to the axillary nodes. Because cancer cells tend to spread through lymph nodes in a specific pattern, doctors can often tell how advanced the cancer is.
Supraclavicular Lymph Nodes
Supraclavicular lymph nodes are located just above the collarbone (clavicle). Most of the time, the enlargement of supraclavicular lymph nodes is a sign of a serious disease such as lung cancer or lymphoma (a type of blood cancer).
Mediastinal Lymph Nodes
Mediastinal lymph nodes reside in the center of the chest cavity between the lungs. People cannot feel mediastinal lymph nodes, but they can be seen in imaging studies such as a CT scan or positron emission tomography (PET) scan.
Checking mediastinal lymph nodes is essential to the staging of lung cancer and some lymphomas.
Inguinal Lymph Nodes
Inguinal lymph nodes are located in the groin. Because they are responsible for filtering lymphatic fluids from the feet to the groin, they can become swollen for many reasons. These include injuries, sexually transmitted diseases, skin infections, yeast infections, and cancer.
Retroperitoneal Lymph Nodes
Retroperitoneal lymph nodes are situated at the back of the abdomen behind the tissues that cover the abdominal wall. These are the nodes to which testicular cancer first spreads. They can only be seen in imaging studies.
Mesenteric Lymph Nodes
Mesenteric lymph nodes lie deep within the abdomen in the membranes that surround the intestine. These nodes often become swollen due to gastroenteritis (stomach flu) but are also sometimes affected by inflammatory bowel disease (IBD) and lymphoma.
Pelvic Lymph Nodes
Pelvic lymph nodes are situated in the lower abdomen in the area that contains the hip bones, bladder, rectum, and reproductive organs. Pelvic lymph nodes are only seen in imaging studies. Swollen pelvic lymph nodes may be a sign of bladder, prostate, cervical, ovarian, or anal cancer.
Where Lymph Nodes Are Located
Lymph nodes are classified by their location, including:
- Axillary lymph nodes (armpits)
- Cervical lymph nodes (neck)
- Inguinal lymph nodes (groin)
- Mediastinal lymph nodes (in the chest cavity)
- Pelvic lymph nodes (in the pelvis)
- Retroperitoneal lymph nodes (back of the abdomen)
- Supraclavicular lymph nodes (above the collarbone)
Associated Conditions
There are many conditions that can directly or indirectly affect the lymph nodes. Some are relatively mild and treatable, while others are more serious.
Lymphadenopathy
Lymphadenopathy, or the swelling of lymph nodes, is not a disease but a symptom of a disease. Based on its location and features, lymphadenopathy can reveal a lot about what is going on inside the body.
The features of lymphadenopathy may be described as:
- Mobile vs. fixed: Mobile lymph nodes are those that can be easily moved, while fixed lymph nodes are stuck to an internal structure. Mobile nodes are generally benign (non-cancerous), while fixed nodes are commonly seen with cancer.
- Painful vs. non-painful: Tender lymph nodes generally occur with infections, while cancerous nodes are typically non-tender.
- Localized vs. generalized: Localized lymphadenopathy, which affects one part of the body, is often due to a local infection such as strep throat. Generalized lymphadenopathy, affecting many parts of the body, can occur with autoimmune diseases, cancer, or drug reactions.
Verywell / Brianna Gilmartin
Lymphadenitis/Lymphangitis
Lymph nodes can "catch" viruses and bacteria but are also susceptible to infections themselves.
- Lymphadenitis is the enlargement in one or more lymph nodes, usually due to an infection.
- Lymphangitis is inflammation of lymphatic vessels, mainly due to an infection, that can involve lymph nodes as well
One such example is a bacterial infection from cats called cat scratch fever. The disease can cause swollen lymph nodes that last for months as well as fever, muscle aches, and nausea.
Cancer
Lymph nodes are commonly involved with cancer, but their role differs based on whether a solid tumor or lymphoma is involved.
With solid tumors such as breast cancer, cancer cells usually travel to nearby lymph nodes before metastasizing (spreading to other parts of the body).
Solid tumor cancers are typically staged based on the TNM system. The TNM system describes the severity of the disease based on the size of the tumor (T), the number and location of lymph nodes with cancer (N), and the presence or absence of metastasis (M).
With lymphoma, cancer starts in the lymph nodes. When lymphomas spread to other parts of the body, it is not referred to as metastasis but rather as "extranodal involvement."
Lymphoma is staged based on the number and location of affected lymph nodes, whether one or both sides of the body are involved, and if there is extranodal involvement.
Conditions Affecting Lymph Nodes
Conditions that directly or indirectly affect the lymph nodes include:
- Lymphadenopathy: Swollen lymph glands causes by the presence of an infection or disease somewhere in the body
- Lymphadenitis: Swollen lymph nodes caused by an infection of the lymph nodes
- Lymphangitis: Inflammation of lymphatic vessels that can also affect the lymph nodes
- Cancer: Either caused by the spread of cancer to a lymph node or by a cancer that starts in the lymph nodes (lymphoma)
Cancer Diagnosis
Summary
Lymph nodes are small, bean-shaped organs that support the immune system by trapping foreign agents and killing them. They do so by filtering bacteria, viruses, and other disease-causing agents circulating in the lymphatic system. White blood cells, called lymphocytes, are then recruited to control infection.
Lymph nodes are clustered throughout the body, including the neck (cervical lymph nodes), groin (inguinal lymph nodes), and armpits (axillary lymph nodes). There are internal lymph nodes in the abdomen (mesenteric and retroperitoneal), chest cavity (mediastinal), and lower abdomen (pelvic).
Swollen lymph nodes (lymphadenopathy) can occur in response to an infection or disease in any part of the body. When a lymph node is infected and becomes swollen, it is referred to as lymphadenitis. Cancer can also affect lymph nodes either as it spreads from a tumor or starts in the lymph nodes themselves (lymphoma).
Frequently Asked Questions
Where are my lymph nodes?
There are about 600 lymph nodes spread throughout the body, such as in the neck, behind the ear, in the legs, and in the abdomen. The major clusters of lymph nodes are in the armpit, groin, and neck.
Learn More: How to Find Lymph Nodes
Why do lymph nodes get swollen?
Swollen lymph nodes are a sign that your body is fighting an infection. When a virus or bacteria gets trapped inside a lymph node, white blood cells called lymphocytes aggressively attack. The resulting inflammation causes the lymph nodes to enlarge.
Lymph nodes can also become enlarged if cancer cells spread to them and grow.
Learn More: 5 Things To Know About Lymphocytes
What do cancerous lymph nodes feel like?
Cancerous lymph nodes tend to be enlarged, painless, and feel rubbery when pressed. They are usually fixed rather than moveable.
Where are the 4 main locations of lymph nodes in the body?
Lymph nodes are small, bean-shaped organs that are the size of a pea. You have nodes throughout your body including in your armpits, neck and groin..Armpit (axillary)..Chest..Abdomen..Groin..Behind your ear..What are the 7 major locations of lymph nodes?
Lymph nodes are classified by their location, including:.Axillary lymph nodes (armpits).Cervical lymph nodes (neck).Inguinal lymph nodes (groin).Mediastinal lymph nodes (in the chest cavity).Pelvic lymph nodes (in the pelvis).Retroperitoneal lymph nodes (back of the abdomen).Where are most cancerous lymph nodes located?
Hundreds of these nodes cluster throughout the lymphatic system, for example, near the knee, groin, neck and armpits. The nodes are connected by a network of lymphatic vessels. Lymphoma is a cancer of the lymphatic system, which is part of the body's germ-fighting network.How many total lymph nodes are in the body?
Lymph nodes are found at the convergence of major blood vessels, and an adult will have approximately 800 nodes commonly sited in the neck, axilla, thorax, abdomen, and groin. These filter incoming lymph and play a role in infection as well as in malignancy.