Why has my veterinarian prescribed this medicine?
This triple antibiotic solution or ointment is used to treat surface bacterial infections of the eye. These infections may occur in the cornea (clear part of eye) or in the conjunctiva (pink parts around eyelids).
How do I give this medication?
- Instill the drops in the pet's eye(s) as directed by your veterinarian. READ THE LABEL CAREFULLY.
- Wash your hands before and after administering the antibiotic.
- Do not touch the eye with the tip of the dropper or tube
- DO NOT give the pet more medicine than directed and do not give more often than directed.
- Try not to miss giving any doses.
- This medication may cause stinging upon application.
What do I do if I miss giving a dose?
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.
How do I store this medicine?
- Keep this medicine out of reach of children.
- Store this medicine in a tight, light resistant container.
What are the potential side effects?
- Triple antibiotic preparations may sting when instilled in the eye.
- Side effects are unusual with this medication.
- If you notice anything unusual, contact your veterinarian.
Are there any possible drug interactions?
- Make sure to tell your veterinarian what other medication you are giving to your pet.
- Quite often, your veterinarian may prescribe two different medications, and sometimes a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
- Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Neomycin and Polymyxin B Sulfates and Dexamethasone Ophthalmic Suspension is a multiple dose anti-infective steroid combination in a sterile suspension for topical application.
Neomycin Sulfate is the sulfate salt of neomycin B and C which are produced by the growth of Streptomyces fradiae Waksman. It has a potency equivalent to not less than 600 micrograms of neomycin base per
milligram, calculated on an anhydrous basis.
Polymyxin B Sulfate is the sulfate salt of Polymyxin B1 and B2 which are produced by the growth of Bacillus polymyxa Migula. It has a potency of not less than 6,000 Polymyxin B units per milligram, calculated on an anhydrous basis.
Indications and Usage:
For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial
ocular infection exists.
Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain cases of infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical radiation or thermal burns; or penetration of foreign bodies.
The use of a combination drug
with an anti-infective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
Dosage:
Apply to 1-2 drops to eye(s) every 4 to 6 hours
Contraindications:
Epithelial herpes simplex keratitis, vaccinia, varicella and many other viral diseases of the cornea and conjunctiva. Mycobacterial
infection of the eye. Fungal diseases of ocular structures. Hypersensitivity to a component of the medication.
Pregnancy. Pregnancy C:
Dexamethasone has been shown to be Teratogenic in mice and rabbits following topical ophthalmic application in multiples of the therapeutic dose.
In the mouse, corticosteroids produce fetal resorptions and a specific abnormality, cleft palate. In the rabbit, corticosteroids have produced fetal resorptions and
multiple abnormalities involving the head, ears, limbs, palate, etc.
There are no adequate or well-controlled studies in pregnant in women. Neomycin, Polymyxin B Sulfates and Dexamethasone Ophthalmic Ointment should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be observed carefully for signs of
hypoadrenalism.
Adverse Reactions:
Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available since no denominator of treated patients is available.
Reactions occurring most often from the presence of the anti-infective ingredients are allergic sensitizations. The reactions due to the
steroid component are; elevation of intraocular pressure with possible development of glaucoma, and infrequent optic nerve damage; posterior sub capsular cataract formation; and delayed wound healing.
Secondary Infection:
The development of secondary infection has occurred after use of combinations containing steroids and antimicrobials. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of
steroids. The possibility of fungal invasion must be considered in any persistent corneal ulceration where steroid treatment has been used.
Secondary bacterial ocular infection following suppression of host responses also occurs.
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