Clinical Trial
Effect of chlorhexidine rinse on the incidence of dry socket in impacted mandibular third molar extraction sites
F L Bonine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb.
Abstract
This nonrandomized prospective study was conducted in a private practice setting to determine the effect of a 0.12% chlorhexidine gluconate rinse (Peridex, Proctor and Gamble, Cincinnati, Ohio) on the incidence of dry socket after removal of impacted mandibular third molars. Over a 3-year period, 371 patients (total of 654 impacted mandibular third molars) received either no treatment (group 1), 2 weeks of twice daily Peridex rinse postsurgery (group 2), or one rinse presurgery (group 3). The group that used Peridex twice daily for 2 weeks after surgery (group 2) showed a significant reduction (56%) in the incidence of dry socket when compared with either the group that did not rinse (group 1) or the group that rinsed only once just before surgery (group 3). The incidence of dry socket was higher in smokers and in females who used oral contraceptives. Twice daily use of Peridex for 2 weeks also yielded significant reductions in dry socket in smokers, nonsmokers, and in females who did not use oral contraceptives. Results from this study demonstrate that the use of Peridex for 2 weeks after surgery is effective in prevention of dry socket after surgical extraction of impacted molars.
Similar articles
Effects of a chlorhexidine gluconate oral rinse on the incidence of alveolar osteitis in mandibular third molar surgery.
Berwick JE, Lessin ME. Berwick JE, et al. J Oral Maxillofac Surg. 1990 May;48(5):444-8; discussion 449. doi: 10.1016/0278-2391(90)90227-s. J Oral Maxillofac Surg. 1990. PMID: 2329393 Clinical Trial.
Perioperative use of 0.12% chlorhexidine gluconate for the prevention of alveolar osteitis: efficacy and risk factor analysis.
Hermesch CB, Hilton TJ, Biesbrock AR, Baker RA, Cain-Hamlin J, McClanahan SF, Gerlach RW. Hermesch CB, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Apr;85(4):381-7. doi: 10.1016/s1079-2104(98)90061-0. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998. PMID: 9574945 Clinical Trial.
Comparison of two chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars.
Metin M, Tek M, Sener I. Metin M, et al. J Contemp Dent Pract. 2006 May 1;7(2):79-86. J Contemp Dent Pract. 2006. PMID: 16685298 Clinical Trial.
[Does chlorhexidine work as a preventive treatment for dry socket?].
IJzerman LM. IJzerman LM. Ned Tijdschr Tandheelkd. 2019 Jan;126(1):13-15. doi: 10.5177/ntvt.2019.01.18202. Ned Tijdschr Tandheelkd. 2019. PMID: 30636260 Review. Dutch.
A review of dry socket: a double-blind study on the effectiveness of clindamycin in reducing the incidence of dry socket.
Chapnick P, Diamond LH. Chapnick P, et al. J Can Dent Assoc. 1992 Jan;58(1):43-52. J Can Dent Assoc. 1992. PMID: 1544038 Review.
Cited by
Effects of intraoperative placement of tetracycline, tetracycline + gelatin sponge, and placebo on postoperative pain after mandibular molar extraction: A comparative prospective study.
Patil V, Ramaraj PN, Sharma M, Singh R, George A, Roy B. Patil V, et al. Natl J Maxillofac Surg. 2021 May-Aug;12(2):211-218. doi: 10.4103/njms.NJMS_47_20. Epub 2021 Jul 15. Natl J Maxillofac Surg. 2021. PMID: 34483579 Free PMC article.
The efficacy of chlorhexidine gel in the prevention of alveolar osteitis after mandibular third molar extraction: a systematic review and meta-analysis.
Teshome A. Teshome A. BMC Oral Health. 2017 May 19;17(1):82. doi: 10.1186/s12903-017-0376-3. BMC Oral Health. 2017. PMID: 28526078 Free PMC article. Review.
Effect of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial.
Rubio-Palau J, Garcia-Linares J, Hueto-Madrid JA, González-Lagunas J, Raspall-Martin G, Mareque-Bueno J. Rubio-Palau J, et al. Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20(1):e117-22. doi: 10.4317/medoral.20009. Med Oral Patol Oral Cir Bucal. 2015. PMID: 25475772 Free PMC article. Clinical Trial.
A randomized clinical trial compared the effect of intra-alveolar 0.2 % Chlorohexidine bio-adhesive gel versus 0.12% Chlorohexidine rinse in reducing alveolar osteitis following molar teeth extractions.
Abu-Mostafa NA, Alqahtani A, Abu-Hasna M, Alhokail A, Aladsani A. Abu-Mostafa NA, et al. Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20(1):e82-7. doi: 10.4317/medoral.19932. Med Oral Patol Oral Cir Bucal. 2015. PMID: 25475768 Free PMC article. Clinical Trial.
Evaluation of the perioperative use of 0.2% chlorhexidine gluconate for the prevention of alveolar osteitis after the extraction of impacted mandibular third molars: a clinical study.
Sridhar V, Wali GG, Shyla HN. Sridhar V, et al. J Maxillofac Oral Surg. 2011 Jun;10(2):101-11. doi: 10.1007/s12663-011-0206-0. Epub 2011 Apr 22. J Maxillofac Oral Surg. 2011. PMID: 22654359 Free PMC article.